Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria
| Autor: | Branka Bedenić, Magda Diab-Elschahawi, Gernot Zarfel, Agnes Wechsler-Fördös, Michael Berktold, Andrea J. Grisold, Josefa Luxner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Acinetobacter baumannii
OXA-143 Imipenem Health Toxicology and Mutagenesis Ceftazidime lcsh:Medicine Microbial Sensitivity Tests Tazobactam Meropenem Article beta-Lactamases Microbiology 03 medical and health sciences 0302 clinical medicine Bacterial Proteins meropenem medicine polycyclic compounds Humans 030212 general & internal medicine Acinetobacter pittii 0303 health sciences acinetobacter baumannii acinetobacter pittii OXA carbapenemases OXA-23 imipenem biology 030306 microbiology lcsh:R Public Health Environmental and Occupational Health Acinetobacter biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Anti-Bacterial Agents Carbapenems Austria bacteria Piperacillin medicine.drug Acinetobacter Infections |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 2171, p 2171 (2021) International Journal of Environmental Research and Public Health Volume 18 Issue 4 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Carbapenem-resistant Acinetobacter baumannii is a significant health problem worldwide. A multicenter study on A. baumannii was performed to investigate the molecular epidemiology and genetic background of carbapenem resistance of A. baumannii isolates collected from 2014–2017 in Austria. In total, 117 non-repetitive Acinetobacter spp. assigned to A. baumannii (n = 114) and A. pittii (n = 3) were collected from four centers in Austria. The isolates were uniformly resistant to piperacillin/tazobactam, ceftazidime, and carbapenems, and resistance to imipenem and meropenem was 97.4% and 98.2%, respectively. The most prominent OXA-types were OXA-58-like (46.5%) and OXA-23-like (41.2%), followed by OXA-24-like (10.5%), with notable regional differences. Carbapenem-hydrolyzing class D carbapenemases (CHDLs) were the only carbapenemases found in A.baumannii isolates in Austria since no metallo-β-lactamases (MBLs) nor KPC or GES carbapenemases were detected in any of the isolates. One-third of the isolates harbored multiple CHDLs. The population structure of A. baumannii isolates from Austria was found to be very diverse, while a total of twenty-three different sequence types (STs) were identified. The most frequent was ST195 found in 15.8%, followed by ST218 and ST231 equally found in 11.4% of isolates. Two new ST types, ST2025 and ST2026, were detected. In one A. pittii isolate, blaOXA-143-like was detected for the first time in Austria. |
| Databáze: | OpenAIRE |
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