Influence of surgical decompression on the expression of inflammatory and tissue repair biomarkers in periapical cysts
| Autor: | Henrique dos Santos Antunes, Fábio Ramôa Pires, Janderson Teixeira Rodrigues, Luciana Armada |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male musculoskeletal diseases Pathology medicine.medical_specialty Adolescent Decompression Interleukin-1beta Enucleation Pathology and Forensic Medicine Proinflammatory cytokine Transforming Growth Factor beta1 03 medical and health sciences Surgical decompression 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Epidermal growth factor receptor Aged Cell Proliferation Radicular Cyst biology Tumor Necrosis Factor-alpha business.industry 030206 dentistry Middle Aged Decompression Surgical Immunohistochemistry Epithelium ErbB Receptors Ki-67 Antigen medicine.anatomical_structure Matrix Metalloproteinase 9 030220 oncology & carcinogenesis biology.protein Female Surgery Oral Surgery Tomography X-Ray Computed business Biomarkers |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 124:561-567 |
| ISSN: | 2212-4403 |
| Popis: | Objective The biologic effects of surgical decompression on the epithelium and connective tissues of periapical cysts are not fully understood. The aim of this study was to evaluate the expression of tissue repair and inflammatory biomarkers in periapical cysts before and after surgical decompression. Study design Nine specimens of periapical cysts treated with decompression before undergoing complete enucleation were immunohistochemically analyzed to investigate the expression of interleukin-1β, tumor necrosis factor-α, transforming growth factor-β1, matrix metalloproteinase-9, Ki-67, and epidermal growth factor receptor. Expression of the biomarkers was classified as positive, focal, or negative. Ki-67 immunoexpression was calculated as a cell proliferation index. The expression of the biomarkers was compared in the specimens from decompression and from the final surgical procedure. Results Computed tomography demonstrated that volume was reduced in all cysts after decompression. There were no differences in the immunoexpression of the proinflammatory and tissue repair biomarkers when comparing the specimens obtained before and after the decompression. Conclusions Surgical decompression was efficient in reducing the volume of periapical cysts before complete enucleation. When comparing the specimens obtained from surgical decompression and from complete surgical removal, the immunohistochemical analysis did not show a decrease in proinflammatory biomarkers; neither did it show an increase in tissue repair biomarkers. |
| Databáze: | OpenAIRE |
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