Determination of antihypertensive drug moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate at carbon paste electrode
| Autor: | Ali K. Attia |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Detection limit
Chromatography Chemistry Chemistry Pharmaceutical Peak current Sodium Dodecyl Sulfate Hydrogen-Ion Concentration Electrochemistry Carbon Analytical Chemistry Carbon paste electrode Ointments chemistry.chemical_compound Kinetics Surface-Active Agents Moexipril Hydrochloride Tetrahydroisoquinolines Differential pulse voltammetry Sodium dodecyl sulfate Quantitative analysis (chemistry) Electrodes Antihypertensive Agents |
| Zdroj: | Talanta. 81(1-2) |
| ISSN: | 1873-3573 |
| Popis: | Herein, an electrochemical differential pulse voltammetric method was developed for the determination of moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate. The oxidation process has been carried out in Britton-Robinson buffer. Moexipril hydrochloride exhibits a well-defined irreversible oxidation peak over the entire pH range (2–11). The peak current varied linearly over the range from 4.0 × 10 −7 to 5.2 × 10 −6 mol L −1 . The limits of detection and quantification were 6.87 × 10 −8 mol L −1 and 2.29 × 10 −7 mol L −1 , respectively. The recovery was found in the range from 99.65% to 100.76%. The relative standard deviation was found in the range from 0.429% to 0.845%. The proposed method possesses high sensitivity, accuracy and rapid response. Finally, this method was successfully used to determine moexipril hydrochloride in tablets. |
| Databáze: | OpenAIRE |
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