Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma

Autor: Matthew J. Weiss, Sorin Alexandrescu, Timothy M. Pawlik, B. Groot Koerkamp, Carlo Pulitano, Fabio Bagante, Todd W. Bauer, Gaya Spolverato, Hugo Marques, Oliver Soubrane, Endo Itaru, Guillaume Martel, Alfredo Guglielmi, Shishir K. Maithel, Feng Shen, George A. Poultsides, Luca Aldrighetti
Přispěvatelé: Bagante, F, Spolverato, G, Weiss, M, Alexandrescu, S, Marques, Hp, Aldrighetti, L, Maithel, Sk, Pulitano, C, Bauer, Tw, Shen, F, Poultsides, Ga, Soubrane, O, Martel, G, Koerkamp, Bg, Guglielmi, A, Itaru, E, Pawlik, Tm, Surgery
Rok vydání: 2017
Předmět:
Oncology
Male
Poor prognosis
medicine.medical_specialty
Survival
medicine.medical_treatment
Bile Duct Neoplasms/mortality
Cholangiocarcinoma/mortality
Cholangiocarcinoma/pathology
Cholangiocarcinoma
Intrahepatic
Long-term
030230 surgery
Bile Duct Neoplasms/surgery
Gastroenterology
Resection
03 medical and health sciences
0302 clinical medicine
Bile Ducts
Intrahepatic/surgery
Cancer Survivors
Internal medicine
medicine
Humans
Hepatectomy
Neoplasm Invasiveness
Survival rate
Pathological
Bile Duct Neoplasms/pathology
Intrahepatic Cholangiocarcinoma
Aged
Cholangiocarcinoma/surgery
business.industry
Incidence (epidemiology)
Liver Neoplasms
Middle Aged
medicine.disease
HCC CIR
Primary tumor
Survival Rate
Bile Ducts
Intrahepatic
Bile Duct Neoplasms
Liver Neoplasms/secondary
030220 oncology & carcinogenesis
Surgery
Female
business
Zdroj: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Journal of Gastrointestinal Surgery, 21(11), 1888-1897. Springer New York
ISSN: 1091-255X
Popis: BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary tumor of the liver. While surgery remains the cornerstone of therapy, long-term survival following curative-intent resection is generally poor. The aim of the current study was to define the incidence of actual long-term survivors, as well as identify clinicopathological factors associated with long-term survival. METHODS: Patients who underwent a curative-intent liver resection for ICC between 1990 and 2015 were identified using a multi-institutional database. Overall, 679 patients were alive with ≥ 5 years of follow-up or had died during follow-up. Prognostic factors among patients who were long-term survivors (LT) (overall survival (OS) ≥ 5) were compared with patients who were not non-long-term survivors (non-LT) (OS 5 cm (OR 2.40, 95% CI, 1.54-3.74, p < 0.001), and direct invasion of an adjacent organ (OR 3.98, 95% CI, 1.18-13.4, p = 0.026). However, a subset of patients (
Databáze: OpenAIRE
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