Ocular preservatives: associated risks and newer options
| Autor: | Indu Pal Kaur, Harinder Singh, Cheena Rana, Shruti Lal, Shilpa Kakkar |
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| Rok vydání: | 2009 |
| Předmět: |
Risk
Preservative business.industry Chlorobutanol Preservatives Pharmaceutical Epithelial Cells General Medicine Pharmacology Toxicology Eye Chlorhexidine Acetate chemistry.chemical_compound Benzalkonium chloride chemistry Toxicity Tests Medicine Humans Phenylmercuric nitrate Sodium perborate Ophthalmic Solutions business Cells Cultured medicine.drug |
| Zdroj: | Cutaneous and ocular toxicology. 28(3) |
| ISSN: | 1556-9535 |
| Popis: | Presence of a preservative in an ocular medication has often been considered a culprit in damaging the epithelium. However, the inclusion of a preservative is equally necessary, especially in multiple-dose containers, in order to protect against dangerous organisms accidentally gaining access during instillation. Benzalkonium chloride (BAK), chlorobutanol, chlorhexidine acetate (CHA), and phenylmercuric nitrate or acetate are some commonly used preservatives in eye preparations. New preservatives with a wide range of activity and good safety profiles have been introduced in the market, such as stabilized oxychloro complex (SOC), sofZia, and sodium perborate. In the present review, we discuss various conventional and newly proposed and patented preservative molecules for ocular use. Reasons for discontinuing traditional preservatives and the need for less-toxic molecules are discussed at length, along with newer options coming up in this area. |
| Databáze: | OpenAIRE |
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