Clinical evaluation of teicoplanin for therapy of severe infections caused by gram-positive bacteria
| Autor: | Françoise Crokaert, F. Meunier-Carpentier, Eugène Yourassowsky, J. P. Kains, E Serruys-Schoutens, P. Van der Auwera, Hjalmar Lagast, Jean-Pierre Thys, Youri Glupczynski, Jean Klastersky |
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| Jazyk: | angličtina |
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause Gram-Positive Bacteria Gastroenterology Microbiology Staphylococcus epidermidis Internal medicine Streptococcus pneumoniae medicine Endocarditis Humans Pharmacology (medical) Aged Pharmacology biology Streptococcus Teicoplanin business.industry Glycopeptides Bacterial Infections Middle Aged medicine.disease biology.organism_classification Anti-Bacterial Agents Infectious Diseases Staphylococcus aureus Bacteremia Female business medicine.drug Research Article |
| Popis: | Teicoplanin was evaluated in 47 patients with severe infections, including 14 patients with bone infections, 11 patients with soft-tissue infections, 7 patients with endocarditis, 5 patients with pneumonia, 3 patients with septic thrombophlebitis, 3 patients with septicemia of unknown origin, and 4 patients with miscellaneous infections. Overall, bacteremia was documented in 24 patients. The pathogens isolated were 35 strains of Staphylococcus aureus (including 8 methicillin-resistant strains), 4 strains of Staphylococcus epidermidis, 4 strains of Streptococcus faecalis, 2 strains of Streptococcus pneumoniae, 5 strains of other streptococci, and 1 Micrococcus luteus strain. A total of 22 patients (46.8%) were clinically cured, 8 patients (17.0%) improved, 2 patients (4.3%) had relapses after initial improvement, and 15 patients (31.9%) failed to respond. The results were better in nonbacteremic patients (19 of 23 patients [82.6%] were cured or improved) than in patients with bacteremia (12 of 24 patients [50%] were cured or improved). Bacteriological cure occurred in 25 patients (53.2%), and superinfections were documented in 6 patients (12.8%). No major adverse effects were observed. We conclude that teicoplanin is a potentially effective and well-tolerated antimicrobial agent for therapy of nonbacteremic infections caused by gram-positive bacteria. |
| Databáze: | OpenAIRE |
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