Does intravenous fish oil affect the growth of extremely low birth weight preterm infants on parenteral nutrition?
| Autor: | Adriana Pompilio, Luca Antognoli, Rita D'Ascenzo, Virgilio P. Carnielli, Chiara Biagetti, Paolo Marchionni, Paola Cogo, Alessio Correani, Maria Paola Bellagamba |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Fat Emulsions Intravenous Parenteral Nutrition Birth weight Physiology 030209 endocrinology & metabolism Growth Fish oil Critical Care and Intensive Care Medicine Infant Newborn Diseases 03 medical and health sciences 0302 clinical medicine Fish Oils Fatty Acids Omega-3 medicine Lipid emulsion Omega-3 fatty acids Birth Weight Humans Retrospective Studies 030109 nutrition & dietetics Nutrition and Dietetics business.industry Premature infants Infant Newborn Gestational age Low birth weight Parenteral nutrition Docosahexaenoic acid Infant Extremely Low Birth Weight Cohort Female medicine.symptom business Energy Intake Weight gain Infant Premature |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 38(5) |
| ISSN: | 1532-1983 |
| Popis: | Summary Background & aims Long chain n-3 fatty acids (n-3 LCPUFA) play a pivotal role during central nervous system development and the provision of docosahexaenoic acid (DHA) is recommended for the preterm infant. However, there are concerns that oral fish oil, which is a good source of DHA, may adversely affect growth of preterm infants, as it decreases arachidonic acid (ARA). It has been about ten years since fish oil was added to the fat blend of intravenous (IV) lipid emulsions (LE) but information on growth and other clinical outcomes of preterm infants is still scarce. We studied the effect of fish oil containing IV LE vs standard IV LE on growth in a large cohort of preterm infants who received routine parenteral nutrition (PN). Methods We retrospectively reviewed growth data of 546 preterm infants with a birth weight (BW) Results Demographics, birth data and the incidence of the main complications of prematurity were similar between the two groups (IV-FO: n = 240, Gestational age (GA) 197 ± 16 d, BW 942 ± 181 g; CNTR: n = 237, GA 199 ± 17 d, BW 960 ± 197 g). No difference was found in PN and EN energy and macronutrient intakes from birth to 36+0W PMA, as well as in the proportion of human milk to infant milk formula. Weight gain from the regained BW to 36+0W PMA was slightly but significantly higher in IV-FO group: 17.3 ± 2.8 and 16.8 ± 2.7 g∙kg−1∙d−1, IV-FO and CNTR respectively (p = 0.03). There was no difference in length gain and head growth nor in body size at 36+0W PMA between the two groups. Conclusions The use of IV fish oil did not negatively affect weight gain in a cohort of preterm infants. Large randomized controlled trials are needed to assess the effect of IV fish oil on the complication of prematurity and on selected domains of infant development. |
| Databáze: | OpenAIRE |
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