Analytical and pharmacokinetic studies on butyrophenones
| Autor: | A. Bizzi, Silvio Garattini, Emilio Mussini, Franca Marcucci, Roberto Fanelli, F. De Nadai, Alberto Frigerio, M. Rizzo, Paolo L. Morselli, Luisa Airoldi |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Drug Chromatography Gas Dextroamphetamine Time Factors media_common.quotation_subject Clinical Biochemistry Administration Oral Pharmacology Injections Intramuscular Biochemistry Mass Spectrometry Pharmacokinetics Trifluperidol In vivo Methods medicine Haloperidol Animals Humans Amphetamine media_common Behavior Animal Chemistry Mental Disorders Biochemistry (medical) Brain Fasting General Medicine Butyrophenones In vitro Rats Kinetics Adipose Tissue Dealkylation Depression Chemical Injections Intravenous Microsomes Liver Oxidation-Reduction medicine.drug |
| Zdroj: | Clinica Chimica Acta. 34:321-332 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(71)90186-0 |
| Popis: | A method to measure butyrophenones as such in GLC was developed and applied for the determination of these drugs in biological materials. Haloperidol and trifluperidol show many properties in common when they are injected. They penetrate very rapidly into brain where they reach levels several times higher than in plasma. The brain concentration able to inhibit completely the effects of amphetamine is for both drugs between 30 and 40 ng/g. Haloperidol and trifluperidol are different in their capacity to accumulate in the adipose tissue in vivo and in vitro. The GLC method to measure butyrophenones has been employed for determining haloperidol in the plasma of psychiatric patients treated with this drug for therapeutical reasons. |
| Databáze: | OpenAIRE |
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