Differences in nasal immunoglobulin A responses to influenza vaccine strains after live attenuated influenza vaccine (LAIV) immunization in children
Autor: | R. R. Javan, Paul Turner, Katja Hoschler, John S. Tregoning, Jo Southern, Maria Zambon, A. F. Abdulla, Megan E. Cole, Victoria M. W. Gould, Elizabeth Miller, Megan O'Driscoll, Nick Andrews |
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Přispěvatelé: | Medical Research Council (MRC), Department of Health |
Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine Immunoglobulin A nasal Antibodies Viral Editors' Choice Influenza A Virus H1N1 Subtype 0302 clinical medicine vaccine Immunology and Allergy Live attenuated influenza vaccine Medicine PROTECTION Child biology Immunogenicity public health TRIVALENT 3. Good health Influenza Vaccines 1107 Immunology Child Preschool Original Article Female Nasal Cavity Antibody influenza Life Sciences & Biomedicine Vaccines Live Unattenuated Adolescent Influenza vaccine VIRUSES Immunology UNITED-STATES SEASONAL INFLUENZA 03 medical and health sciences Immune system children Antigen Humans IGA Science & Technology business.industry Influenza A Virus H3N2 Subtype 030104 developmental biology Immunization biology.protein business 030215 immunology |
Zdroj: | Clinical and Experimental Immunology |
ISSN: | 1365-2249 0009-9104 |
Popis: | Summary Different vaccine strains included in the live attenuated influenza vaccine (LAIV) have variable efficacy. The reasons for this are not clear and may include differences in immunogenicity. We report a Phase IV open‐label study on the immunogenicity of a single dose of quadrivalent LAIV (Fluenz™ Tetra) in children during the 2015/16 season, to investigate the antibody responses to different strains. Eligible children were enrolled to receive LAIV; nasal samples were collected before and approximately 4 weeks after immunization. There was a significant increase in nasal immunoglobulin (Ig)A to the H3N2, B/Victoria lineage (B/Brisbane) and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component. The fold change in nasal IgA response was inversely proportional to the baseline nasal IgA titre for H1N1, H3N2 and B/Brisbane. We investigated possible associations that may explain baseline nasal IgA, including age and prior vaccination status, but found different patterns for different antigens, suggesting that the response is multi‐factorial. Overall, we observed differences in immune responses to different viral strains included in the vaccine; the reasons for this require further investigation. Different vaccine strains included in the Live Attenuated Influenza Vaccine (LAIV) have variable efficacy. We performed an immunogenicity study of quadrivalent LAIV in children during the 2015/16 season. There was a significant increase in nasal IgA to the H3N2, B/Victoria lineage (B/Brisbane), and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component. |
Databáze: | OpenAIRE |
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