Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB
Autor: | Fiona Heeman, Nelleke Tolboom, Isadora Lopes Alves, Janine Hendriks, Adriaan A. Lammertsma, Bart N.M. van Berckel, Maqsood Yaqub |
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Přispěvatelé: | Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Internal medicine, Amsterdam Neuroscience - Neurodegeneration, AMS - Tissue Function & Regeneration, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep |
Rok vydání: | 2021 |
Předmět: |
Adult
Male Cancer Research Brief Article Reference tissue [11C]PiB Alzheimer’s disease computer.software_genre 030218 nuclear medicine & medical imaging Retrospective data 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Voxel TRACER Image Processing Computer-Assisted Humans Medicine Cognitive Dysfunction Radiology Nuclear Medicine and imaging Gray Matter [11C]PiB Alzheimer's disease Aged Aniline Compounds business.industry Disease progression Reproducibility of Results Water Cerebral blood flow Treatment efficacy Thiazoles Oncology Test-retest variability Cerebrovascular Circulation Positron-Emission Tomography Linear Models Mixed effects Female Relative tracer delivery Radiopharmaceuticals business Nuclear medicine computer 030217 neurology & neurosurgery |
Zdroj: | Molecular Imaging and Biology Molecular Imaging and Biology, 23(3), 335-339. Springer New York Heeman, F, Hendriks, J, Lopes Alves, I, Tolboom, N, van Berckel, B N M, Yaqub, M & Lammertsma, A A 2021, ' Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB ', Molecular Imaging and Biology, vol. 23, no. 3, pp. 335-339 . https://doi.org/10.1007/s11307-021-01606-z |
ISSN: | 1536-1632 |
DOI: | 10.1007/s11307-021-01606-z |
Popis: | Purpose Moderate-to-high correlations have been reported between the [11C]PiB PET-derived relative tracer delivery rate R1 and relative CBF as measured using [15O]H2O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment efficacy or disease progression, it is important to know the intrinsic variability of R1. The purpose of the present study was to determine this through a retrospective data analysis. Procedures Test-retest data belonging to twelve participants, who underwent two 90 min [11C]PiB PET scans, were retrospectively included. The voxel-based implementation of the two-step simplified reference tissue model with cerebellar grey matter as reference tissue was used to compute R1 images. Next, test-retest variability was calculated, and test and retest R1 measures were compared using linear mixed effect models and a Bland-Altman analysis. Results Test-retest variability was low across regions (max. 5.8 %), and test and retest measures showed high, significant correlations (R2=0.92, slope=0.98) and a negligible bias (0.69±3.07 %). Conclusions In conclusion, the high precision of [11C]PiB R1 suggests suitable applicability for cross-sectional and longitudinal studies. |
Databáze: | OpenAIRE |
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