Adult onset acquired myasthenia gravis in three great dane littermates
| Autor: | G. D. Shelton, M. Kent, E. N. Glass, M. Acierno |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Disease Breeding Dogs Fatal Outcome immune system diseases Postsynaptic potential Myasthenia Gravis Genetic predisposition medicine Animals Genetic Predisposition to Disease Receptors Cholinergic Dog Diseases Small Animals Autoantibodies Acetylcholine receptor Autoimmune disease business.industry Autoantibody medicine.disease Myasthenia gravis Pedigree nervous system diseases Nicotinic agonist Immunology Female business |
| Zdroj: | Journal of Small Animal Practice. 49:647-650 |
| ISSN: | 1748-5827 0022-4510 |
| DOI: | 10.1111/j.1748-5827.2008.00627.x |
| Popis: | Acquired canine myasthenia gravis is an autoimmune disease in which autoantibodies are directed against muscle postsynaptic nicotinic acetylcholine receptors. Three adult great dane littermates were evaluated over a four month time period for an acute onset of generalised neuromuscular signs. All three dogs had elevated serum acetylcholine receptor antibody titres, which were considered diagnostic for acquired myasthenia gravis. Identification of three littermates with acquired myasthenia gravis in a breed with a low relative risk of developing the disease suggests a familial and possibly a genetic predisposition to myasthenia gravis in this family of dogs. |
| Databáze: | OpenAIRE |
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