The use of linezolid in the treatment of vancomycin-resistant enterococcal septicaemia in two patients with burn injuries
| Autor: | L. Teare, N. Hidvegi, J. L. Atkins, Peter Dziewulski |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.drug_class Cephalosporin Antibiotics Drug resistance Critical Care and Intensive Care Medicine medicine.disease_cause Microbiology chemistry.chemical_compound Vancomycin Sepsis Acetamides medicine Humans Oxazolidinones biology business.industry Linezolid Drug Resistance Microbial General Medicine biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses biology.organism_classification Glycopeptide Anti-Bacterial Agents Enterococcus chemistry Staphylococcus aureus Emergency Medicine Surgery business Burns medicine.drug |
| Zdroj: | Burns : journal of the International Society for Burn Injuries. 28(2) |
| ISSN: | 0305-4179 |
| Popis: | Vancomycin-resistant enterococci (VRE) are multi-resistant micro-organisms that have emerged as important nosocomial pathogens during the last decade. Emergence of this organism has been blamed mainly on the increased and inappropriate use of antibiotics, in particular, the cephalosporins and the glycopeptide, vancomycin. Burns patients are highly vulnerable to acquiring VRE infections, being both debilitated and immunocompromised, and often receiving antibiotics that further diminish their intrinsic microbial flora. We report on two patients with large burn injuries who acquired vancomycin-resistant enterococcal septicaemia during their in-patient stay. Both patients were successfully treated using the antibiotic, linezolid. Linezolid is the first in a new class of antibiotics known as the oxazolidinones whose mode of action inhibits early bacterial protein synthesis. Linezolid has a spectrum of activity against Gram-positive micro-organisms including methicillin-resistant Staphylococcus aureus (MRSA) and VRE, and can provide a useful treatment alternative to the glycopeptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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