Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment
| Autor: | Dedduwa Jayatunge Leel Siriwardena, Wanninayake Mudiyanselage Tilakaratne, Primali Rukmal Jayasooriya, Ramya Kumari Gamagedera Dissanayake |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Adolescent medicine.medical_treatment Disease-Free Survival Metastasis Ameloblastoma Young Adult Age Distribution Humans Medicine Neoplasm Metastasis Child General Dentistry Survival rate Aged Aged 80 and over business.industry Odontogenic tumor Neoplasms Second Primary Neck dissection Middle Aged medicine.disease Primary tumor Surgery Radiation therapy Mandibular Neoplasms medicine.anatomical_structure Otorhinolaryngology Cervical lymph nodes Lymphatic Metastasis Neck Dissection Female Oral Surgery business |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 111:734-741 |
| ISSN: | 1079-2104 |
| DOI: | 10.1016/j.tripleo.2010.12.018 |
| Popis: | Objectives The rare malignant odontogenic tumor, metastasizing (malignant) ameloblastoma (METAM) is reviewed with the aim of analyzing the pattern of disease and treatment of cervical metastasis based, on 2005 World Health Organization classification. Study design A total of 65 cases, including reported cases from 1923 to 2009 compatible with the current classification and a new case are reviewed. Results METAM occurred mostly in lungs (71%), followed by cervical lymph nodes (28%). Female-to-male ratio was 1:1.1. Primary tumor was diagnosed in 28% of cases at ages ≤20 years, and maxilla-to-mandible ratio was 1:5.2. The mean disease-free interval and survival for pulmonary metastasis were 14.37 years and 3 years, respectively, and 12.96 years and 6 years for cervical METAM. Five-year survival rate for cervical metastasis treated purely surgically was 71.43%. Conclusions According to the available literature, neck dissection is the treatment of choice for cervical METAM. Evidence for the role of chemotherapy and radiotherapy is not conclusive. |
| Databáze: | OpenAIRE |
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