A Perspective on a Urine-Derived Kidney Tubuloid Biobank from Patients with Hereditary Tubulopathies

Autor:	Frans Schutgens, Maarten B. Rookmaaker, Marianne C. Verhaar
Rok vydání:	2021
Předmět:	Kidney medicine.medical_specialty business.industry Perspective (graphical) Biomedical Engineering MEDLINE Correction Medicine (miscellaneous) Bioengineering Urine Biobank Organoids medicine.anatomical_structure Humans Medicine business Intensive care medicine Biological Specimen Banks
Zdroj:	Tissue Eng Part C Methods
ISSN:	1937-3392 1937-3384
Popis:	Inherited kidney tubulopathies comprise a group of rare diseases with a significant societal impact, as lifelong treatment is often required and no therapies are available to prevent progression of renal damage. Diagnosis of inherited tubulopathies has improved with the advances of next generation sequencing. However, difficulties remain, such as a lack of genotype-phenotype correlation and unknown pathogenicity of newly identified variants. In addition, treatment remains mainly symptomatic. Both diagnosis and treatment can be improved by addition of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbceef1a84ea555603dc940055173f9 https://doi.org/10.1089/ten.tec.2020.0366 Zobrazit plný text záznamu