Assessment of Gap Junction Protein Beta-2 rs3751385 Gene Polymorphism in Psoriasis Vulgaris
| Autor: | Gregory Tripsianis, Anthony Karpouzis, Stavroula Veletza, Elli-Anna Stylianaki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Psoriasis genetics Early-onset psoriasis Transcriptome 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Psoriasis Genotype otorhinolaryngologic diseases medicine Allele Genotyping Psoriasis pathogenesis business.industry Incidence (epidemiology) rs3751385 General Medicine medicine.disease GJB2 Connexin 26 Late-onset psoriasis 030104 developmental biology Immunology Original Article Gene polymorphism business |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr3845 |
| Popis: | Background: Gap junction protein beta 2 (GJB2) upregulation in psoriasis transcriptome analysis as well as connexin 26 (Cx26, encoded by GJB2) expression upregulation in psoriatic plaques has already been substantiated. GJB2 rs72474224 and rs3751385 have been correlated with psoriasis vulgaris incidence in Chinese populations. Here we study the effect of rs3751385 in patients suffering from psoriasis vulgaris in a Caucasian Greek population at the prefecture of Thrace in Northern Greece. Methods: One hundred and seventy-three (111 males and 62 females) psoriatic patients (108 were of early-onset psoriasis) and 171 matched controls were included in the study. Genomic DNA was extracted from peripheral blood leukocytes and genotyping was carried out by polymerase chain reaction-restriction-fragment length polymorphism (PCR-RFLP). Results: A statistically significant lower frequency of C/T genotype in late-onset male psoriasis vulgaris (P = 0.029) as well as of T allele in female early-onset psoriasis vulgaris (P = 0.049) were ascertained. Conclusions: On condition that all other genetic or environmental factors remain stable, the existence and possible interaction between GJB2 rs3751385 C and T alleles in male psoriatic patients may be considered as protective gene component against late-onset psoriasis appearance, while presence of the T allele in female might block the histogenetic mechanisms of early-onset psoriasis lesions. J Clin Med Res. 2019;11(9):642-650 doi: https://doi.org/10.14740/jocmr3845 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|