TRANSMISSION OF NON-A, NON-B HEPATITIS FROM MAN TO CHIMPANZEE
| Autor: | Geronima Pineda-Tamondong, R. J. Gerety, LewellysF. Barker, JayH. Hoofnagle, LeonardB. Seeff, Milton April, JacquesA. Drucker, D. R. Jackson, Edward Tabor |
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| Rok vydání: | 1978 |
| Předmět: |
Male
Hepatitis Viral Human Pan troglodytes Congenital cytomegalovirus infection medicine.disease_cause Virus Serology medicine Animals Humans Aspartate Aminotransferases Hepatitis B virus Hepatitis medicine.diagnostic_test Transmission (medicine) business.industry Alanine Transaminase General Medicine Hepatitis B medicine.disease Virology Liver Hepatitis Viral Animal Liver biopsy Chronic Disease Immunology Female business |
| Zdroj: | The Lancet. 311:463-466 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(78)90132-0 |
| Popis: | Non-A, non-B hepatitis was transmitted to four colony-born chimpanzees by intravenous inoculation of human sera. Two chimpanzees were inoculated with serum from a patient with a clinical and serological diagnosis of chronic non-A, non-B hepatitis whose blood appeared to transmit this disease to a nurse following accidental needle-stick, and the other two chimpanzees were inoculated with serum from either of two former blood-donors whose HBsAg-negative blood appeared to transmit clinically recognisable hepatitis, and who were found to have raised serum-aminotransferase levels 1 1/2 and 5 years later. Serum-aminotransferase levels rose in all four chimpanzees, beginning 2--4 weeks after inoculation: peak alanine-aminotransferase values were 210 to 328 I.U./l. Evidence of hepatitis was present in liver biopsy specimens from all four chimpanzees, beginning 8--10 weeks after inoculation. None showed serological evidence of infection with hepatitis A virus, hepatitis B virus, cytomegalovirus, or Epstein-Barr virus. |
| Databáze: | OpenAIRE |
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