30 years of study of Kingella kingae: post tenebras, lux
| Autor: | Dimitri Ceroni, Gesuele Renzi, Pierre Lascombes, Belaieff Wilson, Victor Dubois-Ferriere, Jacques Schrenzel, Abdessalam Cherkaoui, Léopold Lamah |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Fastidious organism biology Virulence Factors RTX toxin Oropharynx Kingella kingae Nucleic acid amplification technique medicine.disease biology.organism_classification Microbiology Anti-Bacterial Agents Bone Infection Treatment Outcome Carriage Bacteremia Carrier State medicine Humans Endocarditis Gram-Negative Bacterial Infections |
| Zdroj: | Future Microbiology. 8:233-245 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb.12.144 |
| Popis: | Kingella kingae is a Gram-negative bacterium that is today recognized as the major cause of joint and bone infections in young children. This microorganism is a member of the normal flora of the oropharynx, and the carriage rate among children under 4 years of age is approximately 10%. K. kingae is transmitted from child to child through close personal contact. Key virulence factors of K. kingae include expression of type IV pili, Knh-mediated adhesive activity and production of a potent RTX toxin. The clinical presentation of K. kingae invasive infection is often subtle and may be associated to mild-to-moderate biologic inflammatory responses, highlighting the importance a high index of suspicion. Molecular diagnosis of K. kingae infections by nucleic acid amplification techniques enables identification of this fastidious microorganism. Invasive infections typically respond favorably to medical treatment, with the exception of cases of endocarditis, which may require urgent valve replacement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|