Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men
| Autor: | Sørensen, Lars P, Andersen, Iben Rahbek, Larsen, Svend Erik, Søndergaard, Esben, Gormsen, Lars C, Schmitz, Ole, Christiansen, Jens S, Nielsen, Søren |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipose tissue Fatty Acids Nonesterified Lipoproteins VLDL Biology chemistry.chemical_compound Basal (phylogenetics) Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Hyperinsulinemia Humans Insulin Triglycerides Aged Glycated Hemoglobin Cholesterol Cholesterol HDL Fatty Acids nutritional and metabolic diseases Cholesterol LDL Middle Aged medicine.disease Metabolism Clamp Endocrinology Adipose Tissue Diabetes Mellitus Type 2 chemistry Isotope Labeling lipids (amino acids peptides and proteins) Energy Intake Lipoprotein |
| Zdroj: | Sørensen, L P, Andersen, I R, Larsen, S E, Søndergaard, E, Gormsen, L C, Schmitz, O, Christiansen, J S & Nielsen, S 2011, ' Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men ', Diabetes, vol. 60, no. 1, pp. 88-96 . https://doi.org/10.2337/db10-0564 Diabetes |
| Popis: | OBJECTIVE Increased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia. The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type 2 diabetic and healthy (nondiabetic) men. RESEARCH DESIGN AND METHODS Eleven type 2 diabetic and 11 healthy men, matched for BMI and age, were included. Ex vivo-labeled VLDL-TG tracers, blood and breath samples, fat biopsies, indirect calorimetry, and body composition measures were applied to determine VLDL-TG kinetics, VLDL-TG fatty acids (FA) oxidation, and storage in regional adipose tissue before and during a hyperinsulinemic euglycaemic clamp. RESULTS VLDL-TG secretion was significantly greater in diabetic compared with healthy men (basal: 86.9 [31.0] vs. 61.9 [30.0] μmol/min, P = 0.03; clamp: 60.0 [26.2] vs. 34.2 [17.9] μmol · min−1, P = 0.01). The insulin mediated suppression of VLDL-TG secretion was significant in both groups. VLDL-TG clearance was lower in diabetic men (basal: 84.6 [32.7] vs. 115.4 [44.3] ml · min−1, P = 0.08; clamp: 76.3 [30.6] vs. 119.0 [50.2] ml · min−1, P = 0.03). During hyperinsulinemia fractional VLDL-TG FA oxidation was comparable, but in percentage of energy expenditure (EE), significantly higher in diabetic men. Basal VLDL-TG storage was similar, but significantly greater in abdominal compared with leg fat. CONCLUSIONS Increased VLDL-TG in type 2 diabetic men is caused by greater VLDL-TG secretion and less so by lower VLDL-TG clearance. The ability of hyperinsulinemia to suppress VLDL-TG secretion appears preserved. During hyperinsulinemia VLDL-TG FA oxidation is significantly increased in proportion of EE in type 2 diabetic men. Greater basal abdominal VLDL-TG storage may help explain the accumulation of upper-body fat in insulin-resistant individuals. |
| Databáze: | OpenAIRE |
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