Lesion visualization by targeted computed tomography liver enhancement in dogs
| Autor: | Frederick Kelcz, Susan G. Chosy, Benjamin G. Broghammer, Fred T. Lee, Alan H. Rappe, Ian A. Sproat |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Percutaneous Contrast enhancement Iohexol media_common.quotation_subject Iodipamide Contrast Media Pilot Projects Computed tomography Hepatic Veins Sensitivity and Specificity Lesion Dogs Hepatic Artery Hounsfield scale Animals Medicine Contrast (vision) Radiology Nuclear Medicine and imaging media_common Dose-Response Relationship Drug Portography medicine.diagnostic_test Lesion detection business.industry Drug Administration Routes Radiographic Image Enhancement Liver Infarction Radiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Academic Radiology. 2:484-491 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/s1076-6332(05)80404-0 |
| Popis: | We conducted a pilot study to determine the potential advantages of using liver-specific targeted computed tomography (CT) contrast agents for lesion detection.Eight dogs had liver infarcts created by percutaneous injections of ethanol. Each dog underwent CT scans with four imaging techniques: unenhanced, intravenous contrast enhanced (IVCE), CT arterial portography (CTAP), and targeted liver enhancement with iodipamide ethylester (IDE) particles. Lesions were assessed quantitatively to determine liver-to-lesion density differences and the drop in density across liver edge as a quantitative measure of edge sharpness. Expert readers subjectively analyzed data to determine lesion visibility and edge sharpness.Liver-to-lesion density differences were greatest with CTAP (56.4 +/- 35.5 Hounsfield units [H]) followed by IDE (41.1 +/- 7.0 H), i.v. (22.7 +/- 6.0 H), and unenhanced scans (13.6 +/- 4.1 H; ps.05 for CTAP versus unenhanced and IDE versus unenhanced). Edges were best defined both subjectively and quantitatively on IDE-enhanced scans.Targeted liver-specific contrast agents have potential to increase lesion visibility when compared with standard i.v. contrast enhancement of the liver by increasing lesion edge definition and liver-to-lesion attenuation differences. Further work in animal tumor models, and clinical trials as agents become available, appears justified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|