Usefulness of 99mTc-Sestamibi Scintigraphy in Suggesting the Therapeutic Effect of Chemotherapy against Gastric Cancer
| Autor: | Michiyuki Kanai, Arimichi Takabayashi, Kenji Kawata, Shingo Iwata, Tetsuro Sasada, Naritaka Yamamoto |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Oncology Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Scintigraphy Malignancy Stomach Neoplasms Internal medicine medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Radionuclide Imaging Stomach cancer Aged Epirubicin Chemotherapy Antibiotics Antineoplastic medicine.diagnostic_test business.industry Therapeutic effect Cancer Middle Aged medicine.disease Immunohistochemistry Female Fluorouracil Cisplatin Radiopharmaceuticals business medicine.drug |
| Zdroj: | Clinical Cancer Research. 10:3788-3793 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-1072-3 |
| Popis: | Purpose: Imaging with 99mTc-sestamibi (99mTc-MIBI) has been used to assess 170-kDa P-glycoprotein (P-gp) expression and predict chemotherapy responses in several types of malignancy, such as breast and lung cancers. The purpose of this study was to evaluate the relationship between 99mTc-MIBI accumulation in tumors and sensitivity to chemotherapy in gastric cancer patients. Experimental Design: Thirty-six patients with advanced gastric cancer underwent 99mTc-MIBI scintigraphy before chemotherapy. Patients also underwent endoscopic biopsy, and the expression of P-gp or multidrug resistance-associated protein was analyzed by immunohistochemical staining. The relationship between the accumulation of 99mTc-MIBI in tumors and responses to chemotherapy with 5-fluorouracil/cis-diamminedichloroplatinum(II) or epirubicin was examined. Results: Higher accumulation of 9mTc-MIBI in tumors was observed in 25 and 23 of 36 gastric cancer patients at the early (30 min) and delayed (120 min) images, respectively. Accelerated accumulation of 99mTc-MIBI negatively correlates with increased expression of P-gp, but not of multidrug resistance-associated protein, as determined by immunohistochemistry in gastric cancer tissues. The response rate to 5-fluorouracil/cis-diamminedichloroplatinum(II) chemotherapy in patients with high 99mTc-MIBI accumulation (15.4%) was much lower than that in patients with low 99mTc-MIBI accumulation (54.5%). In contrast, patients with high 99mTc-MIBI accumulation show a higher response rate (41.7%) to chemotherapy with epirubicin, which is known to be a substrate of P-gp transporter. Conclusions: 99mTc-MIBI scintigraphy is useful to suggest the responses to chemotherapy of patients with advanced gastric cancer. |
| Databáze: | OpenAIRE |
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