Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system

Autor:	Mark Ladlow, C. M. Griffiths-Jones, David Joszef Tapolczay, Mark D. Hopkin, and Emma Vickerstaffe, Daniel Jönsson, Steven V. Ley
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Sulfonamides Chromatography Time Factors Molecular Structure Chemistry Binary number General Chemistry Combinatorial chemistry Column (database) Sulfonamide Fully automated Reactor system Combinatorial Chemistry Techniques
Zdroj:	Journal of combinatorial chemistry. 9(3)
ISSN:	1520-4766
Popis:	A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step “catch and release” protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb34561b03c0ddd6ab539d726ab66b5 https://pubmed.ncbi.nlm.nih.gov/17348713 Zobrazit plný text záznamu