Correlation of Higher Levels of Soluble TNF-R1 with a Shorter Survival, Independent of Age, in Recurrent Glioblastoma
Autor: | Robert J. Weil, Gene Barnett, Amy S. Nowacki, Ping Huang, Manmeet Ahluwalia, Monica E. Burgett, Lisa M. Grove, Stephanie Bou-Anak, Nehaw Sarmey, Jill S. Barnholtz-Sloan, Richard A. Prayson, Divya Khosla, Mitchell A. Olman, G. Yancey Gillespie, John H. Suh, Mary McGraw, Eunnyung Bae, Saurabh Dahiya, Candece L. Gladson |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Neurology Disease Article 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Receptors Tumor Necrosis Factor Type II Receptor Prospective cohort study Aged Retrospective Studies Aged 80 and over business.industry Cancer Retrospective cohort study Middle Aged medicine.disease Survival Analysis Endothelial stem cell 030104 developmental biology Receptors Tumor Necrosis Factor Type I 030220 oncology & carcinogenesis Immunology Tumor necrosis factor alpha Female Neurology (clinical) Neoplasm Recurrence Local business Glioblastoma |
Popis: | The circulating levels of soluble tumor necrosis factor receptor-1 (sTNF-R1) and sTNF-R2 are altered in numerous diseases, including several types of cancer. Correlations with the risk of progression in some cancers, as well as systemic manifestations of the disease and therapeutic side-effects, have been described. However, there is very little information on the levels of these soluble receptors in glioblastoma (GBM). Here, we report on an exploratory retrospective study of the levels of sTNF-Rs in the vascular circulation of patients with GBM. Banked samples were obtained from 112 GBM patients (66 untreated, newly-diagnosed patients and 46 with recurrent disease) from two institutions. The levels of sTNF-R1 in the plasma were significantly lower in patients with newly-diagnosed or recurrent GBM than apparently healthy individuals and correlated with the intensity of expression of TNF-R1 on the tumor-associated endothelial cells (ECs) in the corresponding biopsies. Elevated levels of sTNF-R1 in patients with recurrent, but not newly-diagnosed GBM, were significantly associated with a shorter survival, independent of age (p = 0.02) or steroid medication. In contrast, the levels of circulating sTNF-R2 were significantly higher in recurrent GBM than healthy individuals and there was no significant correlation with expression of TNF-R2 on the tumor-associated ECs or survival time. The results indicate that larger, prospective studies are warranted to determine the predictive value of the levels of sTNF-R1 in patients with recurrent GBM and the factors that regulate the levels of sTNF-Rs in the circulation in GBM patients. |
Databáze: | OpenAIRE |
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