Urinary podocalyxin as a possible novel marker of intrauterine nephrogenesis and extrauterine podocyte injury
| Autor: | Yusei Ohshima, Taihei Hayashi, Genrei Ohta, Aiko Igarashi, Shuko Tokuriki, Takashi Okuno |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Urinary system Sialoglycoproteins 030232 urology & nephrology Renal function Nephron Podocyte 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Acetylglucosaminidase medicine Humans Fetus Creatinine business.industry Podocytes Infant Newborn Gestational age Nephrons Proteinuria 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Podocalyxin Nephrology Pediatrics Perinatology and Child Health Infant Small for Gestational Age Female Kidney Diseases business beta 2-Microglobulin Biomarkers Infant Premature |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 32(10) |
| ISSN: | 1432-198X |
| Popis: | The number of nephrons at birth is determined during fetal development and is modulated thereafter by postnatal podocyte injury. Hyperfiltration, caused by a reduced number of nephrons, is a risk factor for chronic kidney disease. It is therefore important to monitor the formation of nephrons. Urine samples were collected from infants within 1–2 days of birth, with follow-up sampling for preterm infants at 37–39 weeks of corrected age. Urinary levels of podocalyxin (PCX), β2-microglobulin (β2MG), N-acetyl-s-D-glucosaminidase (NAG), total protein (TP), microalbumin (mAlb) and creatinine were measured and the relationship between these markers evaluated. Seventy-nine neonates were enrolled in this study. Urinary levels of PCX at birth were higher than normal adult reference values, with levels increasing up to a gestational age of 36 weeks (p = 0.0242). At 37–39 weeks corrected age, urinary levels of PCX decreased to adult levels. The levels of PCX in the urine at birth were not correlated to urinary levels of β2MG, NAG, TP and mAlb. An increased urinary level of PCX may be a marker of both active nephron formation and podocyte injury sustained at birth. As such, changes in urinary levels of PCX are likely to reflect adaptation of renal function to the extra-uterine environment. |
| Databáze: | OpenAIRE |
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