Effect of increasing dietary vitamin A on bone density in adult dogs
| Autor: | Robert A. Easter, J M Losonsky, Gail Czarnecki-Maulden, C R Sipe, J L Cline |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Time Factors Bone density Randomized block design chemistry.chemical_element Biology Calcium chemistry.chemical_compound Random Allocation Dogs In vivo Bone Density Internal medicine Genetics medicine Animals Vitamin A Dose-Response Relationship Drug Tibia Retinol Phosphorus General Medicine Alkaline Phosphatase Diet Dose–response relationship Endocrinology medicine.anatomical_structure chemistry Animal Science and Zoology Female Bone marrow Tomography X-Ray Computed Food Science |
| Zdroj: | Journal of animal science. 75(11) |
| ISSN: | 0021-8812 |
| Popis: | There has been an increase in vitamin A fortification of livestock feeds resulting in increased residual vitamin A in organ meats, which are often used in canned dog foods. The effect on bone density of feeding various concentrations of vitamin A in a canned dog food product was investigated. Thirty-two random-source dogs were assigned to four treatments in a randomized complete block design. The diets contained 15,000, 50,000, 116,000, or 225,000 IU vitamin A/1,000 kcal ME. Diets were fed up to 1 yr. Computed tomography was used to determine bone density of the right tibia at 0, 3, 6, 9, and 12 mo. Computed tomography is a more sensitive technique for determining bone density in vivo than conventional x-rays. There were no differences (P > .10) in tibia bone or marrow density in any of the dogs fed the various concentrations of vitamin A. There was no interaction of time x diet on bone density (P > .05) or bone marrow density (P > .05). In addition, there were no changes in serum alkaline phosphatase, calcium, or phosphorus. These results indicate that concentrations of vitamin A three times the recommended maximum safe amount (71,429 IU/1,000 kcal ME) are not detrimental to normal bone health in dogs. Therefore, these data support the hypothesis that canines are less sensitive to excess vitamin A in the diet than some other mammals. |
| Databáze: | OpenAIRE |
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