Lipid composition of hepatocyte plasma membranes from geese overfed with corn
| Autor: | A. Auvergne, R. Babile, M. Candau, M. Bouillier-Oudot, J. L. Cazeils |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Docosahexaenoic Acids Linoleic acid Dietary lipid Phospholipid Palmitic Acid Biochemistry Zea mays Fatty Acids Monounsaturated chemistry.chemical_compound Membrane Lipids Internal medicine Geese medicine Palmitoleic acid Animals chemistry.chemical_classification Arachidonic Acid Phosphatidylethanolamines Organic Chemistry Fatty liver Cell Membrane Fatty acid Lauric Acids Cell Biology medicine.disease Animal Feed Oleic acid Endocrinology chemistry Liver Phosphatidylcholines lipids (amino acids peptides and proteins) Stearic Acids Polyunsaturated fatty acid Oleic Acid |
| Zdroj: | Lipids. 34(9) |
| ISSN: | 0024-4201 |
| Popis: | Twelve-week-old Landes male geese were overfed with corn for 21 d in order to induce liver steatosis (fatty liver). Lipid composition of hepatocyte plasma membranes from fatty livers was compared to that of lean livers obtained from geese fed a normal diet. The ratio cholesterol/phospholipids was higher in fatty hepatocyte plasma membranes (0.63 vs. 0.47), whereas the phospholipid/protein ratio was less than half. Overfeeding induced changes in fatty acid composition of hepatocyte plasma membranes, including a greater than twofold increase in the percentage of oleic acid (29.7 vs. 13.8%) and a somewhat lesser increase in lauric, palmitic, and palmitoleic acid contents of plasma membrane lipids of fatty livers. A concomitant reduction in the proportion of stearic acid (18.4 vs. 25.1%) was also observed. In fatty livers, the increased ratio of saturated to polyunsaturated fatty acids (PUFA) (1.5 vs. 1.0) was related to a significant decrease in PUFA content. Among all the PUFA, only the eicosatrienoic acid (20:3n-9) percentage was increased by liver steatosis. Overfeeding with corn appeared to induce competition between de novo synthesized and dietary fatty acids incorporated in hepatocyte plasma membranes. This resulted in an accumulation of de novo synthesized monounsaturated and derived fatty acids in plasma membranes from overfed birds. A defect in the incorporation of linoleic acid and linoleic- and linolenic-derived PUFA was observed despite the high proportion of these essential fatty acids in the diet. It was concluded that in overfed palmipeds, de novo hepatic lipogenesis prevails over dietary lipid intake to modulate lipid composition of the fatty liver plasma membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink