Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase
| Autor: | Toru Egashira, Kumiko Sakai, Mami Sakurai, Fusako Takayama, Satoshi Yoshida |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Monoamine Oxidase Inhibitors Chemical compound Monoamine oxidase chemistry.chemical_element Zinc Mitochondrion Toxicology Benzoates chemistry.chemical_compound Norepinephrine Spectroscopy Fourier Transform Infrared medicine Animals Rats Wistar Monoamine Oxidase Chromatography High Pressure Liquid Chemistry Brain General Medicine Haplorhini Mitochondria Rats Biochemistry Distilled water Polystyrenes Serotonin Polystyrene medicine.drug |
| Zdroj: | Toxicology letters. 145(2) |
| ISSN: | 0378-4274 |
| Popis: | The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. |
| Databáze: | OpenAIRE |
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