Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes
| Autor: | Andrés Rodriguez, Yolanda Repetto, Marcela Bontá, Juan A. Squella, Arturo San Feliciano, Juan Diego Maya, Pilar Puebla, Soledad Bollo, Manuel Medarde, Ursula Zelada, Rowena Tellez, Luis J. Núñez-Vergara, Esther Caballero, Antonio Morello |
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| Rok vydání: | 2002 |
| Předmět: |
Dihydropyridines
Stereochemistry Trypanosoma cruzi Immunology Nicardipine Respiratory chain Clone (cell biology) Biology Oxygen Consumption Cell Movement medicine Electrochemistry Moiety Parasite hosting Animals Mode of action Pharmacology Felodipine Dihydropyridine Calcium Channel Blockers Trypanocidal Agents Biochemistry Oxidation-Reduction medicine.drug |
| Zdroj: | Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 125(1) |
| ISSN: | 1532-0456 |
| Popis: | A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory chain inhibition appears to be a posible determinant of the trypanosomicidal activity of this compounds. No difference in the action of these derivatives was found among the different parasite strains. For comparative purposes, the inhibitory effects of felodipine and nicardipine are also reported. A good correlation between toxic effects and the easiness of oxidation of the dihydripyridine ring was found. The presence of a fused ring on the dihydropyridine moiety significantly diminished the inhibitory effects. |
| Databáze: | OpenAIRE |
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