Autoimmune syndrome after induction of neonatal tolerance to alloantigens: effects of in vivo treatment with anti-T cell subset monoclonal antibodies

Autor: J Merino, S Schurmans, S Luzuy, S Izui, P Vassalli, P H Lambert
Jazyk: angličtina
Rok vydání: 1987
Předmět:
Antibodies
Monoclonal/ therapeutic use
Antigens
Differentiation
T-Lymphocyte
T-Lymphocytes
Immunology
Kidney Glomerulus
Antibodies
Antinuclear/immunology
Lymphocyte Cooperation
Animals
Newborn/ immunology
chemical and pharmacologic phenomena
Antigen-Antibody Complex
ddc:616.07
Autoantigens
snRNP Core Proteins
Lymphocyte Depletion
Autoimmune Diseases
Mice
Antigen-Antibody Complex/immunology
Autoantigens/immunology
T-Lymphocytes/classification/ immunology
B-Lymphocytes/immunology/transplantation
Immune Tolerance
Immunology and Allergy
Antigens
Ly
Animals
Mice
Inbred C57BL/immunology
Immunoglobulin G/immunology
Autoantibodies
B-Lymphocytes
Mice
Inbred BALB C
SnRNP Core Proteins
H-2 Antigens/administration & dosage/ immunology
Kidney Glomerulus/analysis
Autoimmune Diseases/etiology/immunology/ therapy
H-2 Antigens
Antibodies
Monoclonal
Mice
Inbred BALB C/immunology
Ribonucleoproteins
Small Nuclear
Antigens
Ly/immunology
Mice
Inbred C57BL
Animals
Newborn
Antibodies
Antinuclear
Immunoglobulin G
Antigens
Surface/immunology
Antigens
Surface
Spleen
Autoantibodies/immunology
Spleen/transplantation
Zdroj: Journal of Immunology, Vol. 139, No 5 (1987) pp. 1426-1431
ISSN: 0022-1767
Popis: BALB/c (H-2d) mice rendered tolerant to h-2b alloantigens by neonatal injection of semiallogeneic (C57BL/6 X BALB/c)F1 spleen cells develop autoimmune features due to an abnormal activation of persisting F1 donor B cells. The role of T cells in this autoimmune syndrome was studied by in vivo treatment of tolerant mice with anti-L3T4(GK-1.5) or anti-Ly-2 (H-35-17.2) monoclonal antibodies. The treatment of tolerant mice from day 2 to day 21 of life with anti-L3T4 MAb completely prevented the occurrence of circulating immune complexes of anti-ssDNA anti-Sm and anti-hapten (FITC) IgG antibodies as well as the glomerular deposition of Ig that were usually seen in untreated tolerant mice. This effect persisted for at least 6 wk after stopping this treatment. When the injections of anti-L3T4 MAb were delayed until day 15 of life, a very significant decrease of the autoimmune manifestations was still observed. Treatment of tolerant mice with anti-Ly-2 MAb during the same period had no effects on the autoimmune disease as compared with untreated tolerant mice. No effects on the maintenance of tolerance vs H-2b alloantigens were observed after treatment with anti-L3T4 MAb, as followed by the decrease of CTL and CTL-p alloreactivity and by the persistence of F1 donor B cells, indicated by the presence of Ig bearing the Ighb donor allotype. These results suggest the existence of interactions between L3T4+ T cells and persisting autoreactive B cells from F1 donor origin in the development of the autoimmune syndrome after neonatal induction of transplantation tolerance.
Databáze: OpenAIRE
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