1-(Aminoalkyl)-6-aryl-4-H-s-triazolo[4,3-a][1,4]benzodiazepines with antianxiety and antidepressant activity
| Autor: | VonVoigtlander Pf, Jackson B. Hester, Rudzik Ad |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Apomorphine Stereochemistry medicine.drug_class Substituent Anxiolytic Body Temperature chemistry.chemical_compound Adinazolam Benzodiazepines Mice Structure-Activity Relationship Drug Discovery medicine Animals Behavior Animal Aryl Oxotremorine Yohimbine Drug Synergism Antidepressive Agents Oxygen chemistry Anti-Anxiety Agents Molecular Medicine Antidepressant medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 23(4) |
| ISSN: | 0022-2623 |
| Popis: | A series of 1-(aminoalkyl)-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines has been prepared and evaluated for central nervous system activity. We have found that members of this series have activity in pharmacological test systems designed to detect both anxiolytic and antidepressant activity. Each type of activity could be varied independently by appropriate substituent selections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|