Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea
| Autor: | Panarat Charoenchai, Kanlayanee Sriklung, Prasat Kittakoop, Yodhathai Thebtaranonth, Sutichai Intamas, Namphung Vongvanich |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.drug_class
Stereochemistry Plasmodium falciparum Antitubercular Agents Pharmaceutical Science Microbial Sensitivity Tests Biology Pharmacognosy Asteraceae Antimycobacterial Sesquiterpene Analytical Chemistry chemistry.chemical_compound Antimalarials Inhibitory Concentration 50 Parasitic Sensitivity Tests Cell Line Tumor Drug Discovery medicine Cytotoxic T cell Animals Cytotoxicity Pharmacology Plant Extracts Organic Chemistry Mycobacterium tuberculosis Plant Components Aerial biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Cell culture Vero cell Molecular Medicine Phytotherapy |
| Zdroj: | Planta medica. 72(15) |
| ISSN: | 0032-0943 |
| Popis: | Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 - 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|