TRACE ELEMENTS CONCENTRATIONS ASSOCIATION WITH SCHIZOPHRENIA SYMPTOMS; A CROSS-SECTIONAL STUDY IN CROATIA
| Autor: | Jasna Jurasović, Berislav Momčilović, Igor Filipčić, Ninoslav Mimica, Sandra Vuk Pisk, Ivana Todorić Laidlaw, Sandra Caratan, Stipe Drmić, Žarko Bajić |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Hospitals Psychiatric Male 0301 basic medicine medicine.medical_specialty Adolescent Psychometrics Croatia Cross-sectional study Statistics as Topic schizophrenia bio-elements trace elements BPRS Young Adult 03 medical and health sciences Reference Values Internal medicine Brief Psychiatric Rating Scale medicine Humans Psychiatric hospital Aged Psychiatric Status Rating Scales business.industry Spectrophotometry Atomic Confounding General Medicine Middle Aged medicine.disease Trace Elements Psychiatry and Mental health Maximal correlation Cross-Sectional Studies 030104 developmental biology Schizophrenia Female business Psychopathology |
| Zdroj: | Scopus-Elsevier Psychiatria Danubina Volume 30 Issue 2 |
| ISSN: | 0353-5053 |
| DOI: | 10.24869/psyd.2018.164 |
| Popis: | Background Significant inconsistencies exist in findings on association of bio-elements (BE) concentrations and schizophrenia. Hypothesis of this research was that different concentrations of BE are associated with different psychopathological schizophrenia symptoms. Subjects and methods This cross-sectional study was performed from 2014 to 2016 at Psychiatric Hospital "Sveti Ivan" and University Psychiatric Hospital "Vrapce", Zagreb, Croatia, on the consecutive sample of 67 patients diagnosed with schizophrenia. BE concentrations were measured by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) at the Institute for Medical Research and Occupational Health in Zagreb. Severity of schizophrenia symptoms was assessed on Brief Psychiatric Rating Scale (BPRS). Results After adjustment for all preplanned possible confounding variables, the first canonical correlation between BE and BPRS dimensions variates were statistically significant (Rc2=0.73; P=0.006). The first pair of canonical variates is defined by BPRS negative dimension (and marginally by positive symptoms and lack of resistance), and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co) (marginally by cadmium (Cd) and nickel (Ni)). Conclusions Concentrations of different BE are associated with different schizophrenia symptoms. Maximal correlation between BPRS and BE may be achieved with the weighted linear composite of negative schizophrenia symptoms and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co). |
| Databáze: | OpenAIRE |
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