Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom
| Autor: | Márcio Galdino dos Santos, Yoko Oshima-Franco, Arturo San Feliciano, Luiz Madaleno Franco, Leandro Rubem-Mauro, Renata V. da Silva, Pilar Puebla |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Diaphragm Pharmaceutical Science Poison control In Vitro Techniques Article Mass Spectrometry Protocatechuic acid Analytical Chemistry lcsh:QD241-441 Mice chemistry.chemical_compound lcsh:Organic chemistry Crotalid Venoms Drug Discovery Botany Aurone Vanillic acid Animals Bothrops Physical and Theoretical Chemistry Dipteryx snake venom Lupeol Betulin Molecular Structure biology Traditional medicine Plant Extracts Dipteryx alata Organic Chemistry neutralization biology.organism_classification Isoflavones Triterpenes Phrenic Nerve Bothrops jararacussu chemistry Chemistry (miscellaneous) Neuromuscular Blockade Plant Bark Molecular Medicine Pentacyclic Triterpenes Leguminosae-Papilionoideae Isoliquiritigenin isoflavone |
| Zdroj: | Molecules; Volume 15; Issue 11; Pages: 8193-8204 Molecules Molecules, Vol 15, Iss 11, Pp 8193-8204 (2010) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules15118193 |
| Popis: | The effect of four sub-extracts prepared from the lyophilized hydroalcoholic bark of Dipteryx alata (Leguminosae-Papilionoideae) dissolved in a methanol-water (80:20) mixture through a liquid-liquid partition procedure has been investigated against the neuromuscular blockade of the venom of the snake Bothrops jararacussu. The active CH2Cl2 sub-extract has been extensively analyzed for its chemical constituents, resulting in the isolation of four lupane-type triterpenoids: lupeol (1), lupenone (2), 28-hydroxylup-20(29)-en-3-one (3), betulin (4), nine isoflavonoids: 8-O-methylretusin (5), 7-hydroxy-5,6,4’-trimethoxyisoflavone (6), afrormosin (8), 7-hydroxy-8,3’,4’-trimethoxyisoflavone (9), 7,3’-dihydroxy-8,4’-dimethoxyisoflavone (10), odoratin (11), 7,8,3’-trihydroxy-4’-methoxyisoflavone (13), 7,8,3’-trihydroxy-6,4’-dimethoxyisoflavone (15), dipteryxin (17), one chalcone: isoliquiritigenin (7), one aurone: sulfuretin (14) and three phenolic compounds: vanillic acid (12), vanillin (16), and protocatechuic acid (18). Their chemical structures were elucidated on the basis of spectroscopic analysis, including HRMS, 1D- and 2D-NMR techniques. |
| Databáze: | OpenAIRE |
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