Interferons in the Therapy of Severe Coronavirus Infections: A Critical Analysis and Recollection of a Forgotten Therapeutic Regimen with Interferon Beta
| Autor: | Manfred Hündgen, Harald von Eick, Josef Brzoska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Coronaviridae Infections
drug research infectious diseases 01 natural sciences Antiviral Agents 03 medical and health sciences antiviral drugs 0302 clinical medicine Interferon MERS Drug Discovery Opinion Paper Medicine Animals Humans immunopharmacology SARS Therapeutic regimen Interferon beta Recombinant interferon Host Microbial Interactions 010405 organic chemistry business.industry SARS-CoV-2 Multiple sclerosis COVID-19 General Medicine medicine.disease human pharmacology Immunopharmacology cytokines 0104 chemical sciences Coronavirus Regimen Treatment Outcome 030220 oncology & carcinogenesis Immunology business Coronavirus Infections Interferon beta-1a medicine.drug |
| Zdroj: | Drug Research |
| ISSN: | 2194-9387 2194-9379 |
| Popis: | The pharmacological and immunological properties of interferons, especially those of interferon beta, and the corresponding treatment strategies are described, and the results of studies with different interferons in coronavirus infections are analysed. Furthermore, the data obtained with high-dosed native interferon beta in life-threatening acute viral diseases as well as the results of clinical pilot studies with high-dosed recombinant interferon beta-1a are provided because they serve as the rationale for the proposed therapeutic regimen to be applied in acute viral infections. This regimen differs from those approved for treatment of multiple sclerosis and consists of interferon beta-1a administered as a 24 hour intravenous infusion at a daily dose of up to 90 µg for 3–5 consecutive days. Since under this regimen transient severe side effects can occur, it is analysed which patients are suitable for this kind of treatment in general and if patients with severe coronavirus infections could also be treated accordingly. |
| Databáze: | OpenAIRE |
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