Age patterning in wild chimpanzee gut microbiota diversity reveals differences from humans in early life
| Autor: | John C. Mitani, Leah A. Owens, Zarin P. Machanda, Emily M. Venable, Richard W. Wrangham, Kevin E. Langergraber, Martin N. Muller, David P. Watts, Aspen T. Reese, Melissa Emery Thompson, Sarah Renee Phillips, Tony L. Goldberg, Rachel N. Carmody |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Change over time Pan troglodytes Zoology Gut flora General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Immune system Plant matter biology.animal Animals Humans Primate Colonization Microbiome biology Bacteria Microbiota Infant Newborn Infant biology.organism_classification Early life Gastrointestinal Microbiome 030104 developmental biology General Agricultural and Biological Sciences human activities 030217 neurology & neurosurgery |
| Zdroj: | Curr Biol |
| Popis: | Summary Survival in primates is facilitated by commensal gut microbes that ferment otherwise indigestible plant matter, resist colonization by pathogens, and train the developing immune system. 1 , 2 However, humans are unique among primates in that we consume highly digestible foods, wean early, mature slowly, and exhibit high lifelong investments in maintenance. 3 , 4 , 5 , 6 These adaptations suggest that lifetime trajectories of human-microbial relationships could differ from those of our closest living relatives. Here, we profile the gut microbiota of 166 wild chimpanzees aged 8 months to 67 years in the Kibale National Park, Uganda and compare the patterns of gut microbial maturation to those previously observed in humans. We found that chimpanzee gut microbial alpha-diversity, composition, density, interindividual variation, and within-individual change over time varied significantly with age. Notably, gut microbial signatures in infants |
| Databáze: | OpenAIRE |
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