Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium
| Autor: | Miwa Miyauchi, Takenori Ishikawa, Shigehiro Ono, Masaru Sugiyama, Tamiko Dohmen, Ujjal K. Bhawal |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Epithelial dysplasia Pathology medicine.medical_specialty medicine.disease_cause Epithelium Statistics Nonparametric Virus law.invention law Tumor Cells Cultured Carcinoma medicine Humans Papillomaviridae General Dentistry Polymerase chain reaction Aged Aged 80 and over Mouth neoplasm biology Papillomavirus Infections Age Factors Mouth Mucosa virus diseases Middle Aged medicine.disease biology.organism_classification Tumor Virus Infections stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Lymphatic Metastasis DNA Viral Carcinoma Squamous Cell Disease Progression Female Mouth Neoplasms Surgery Oral Surgery Carcinogenesis Precancerous Conditions |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 95:594-600 |
| ISSN: | 1079-2104 |
| DOI: | 10.1067/moe.2003.36 |
| Popis: | Objective. Our aim was to clarify the association of human papillomavirus (HPV) with oral carcinogenesis, especially its early stage. Study Design. Tissue specimens of normal mucosa, epithelial dysplasia, oral squamous cell carcinoma (OSCC), and OSCC cell lines were examined for the presence of HPV-16 and HPV-18 E6 DNA by means of the polymerase chain reaction test. Results. The detection rate of HPV-16 in epithelial dysplasia (31/51) was higher than that in normal mucosa (16/44) and in OSCC (30/86) and was statistically different from that in OSCC. The cases that progressed from epithelial dysplasia to carcinoma showed a significantly higher HPV-16 detection rate than the other cases in both epithelial dysplasia and OSCC. HPV-16 and HPV-18 were detected only at early passages of 2 of 10 OSCC cell lines. Conclusion. These results strongly suggest that HPV-16 may be involved in the early stages of the development of some oral carcinomas. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:594-600) |
| Databáze: | OpenAIRE |
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