Association of XRCC3 18067 CT (Thr241Met) polymorphism with risk of cervical and ovarian cancers: A systematic review and meta-analysis
| Autor: | Hossein Neamatzadeh, Mansour Moghimi, Atiyeh Javaheri, Mojgan Karimi-Zarchi, Hajar Abbasi, Amaneh Hadadan, Razieh Sadat Tabatabaei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cervical cancer 0303 health sciences medicine.medical_specialty business.industry XRCC3 gene General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine XRCC3 030220 oncology & carcinogenesis Internal medicine Meta-analysis medicine Ovarian cancer business 030304 developmental biology |
| Zdroj: | Interventional medicineapplied science. 11(3) |
| ISSN: | 2061-1617 |
| Popis: | The 18067 C>T polymorphism of XRCC3 gene has been considered to be implicated in the development of cervical and ovarian cancers, but the results are inconsistent. Thus, we conducted a meta-analysis to assess the association of XRCC3 18067 C>T polymorphism with risk of cervical and ovarian cancers. All studies on the association of XRCC3 18067 C>T polymorphism with cervical and ovarian cancers risk were retrieved. Finally, a total of 17 studies including 10 studies with 5,637 cases and 10,057 controls on ovarian cancer and 7 studies with 1,112 cases and 1,233 controls on cervical cancer were selected. Overall, pooled results showed that the XRCC3 18067 C>T polymorphism was significantly associated with increased risk of ovarian cancer (TC vs. CC: OR = 0.904, 95% CI = 0.841–0.972, p = 0.006; TT + TC vs. CC: OR = 0.914, 95% CI = 0.853–0.979, p = 0.010) and cervical cancer (TC vs. CC: OR = 1.00, 95% CI = 1.066–1.585, p = 0.009). Further subgroup analysis by ethnicity revealed an increased risk of cervical and ovarian cancer in Asians and Caucasians, respectively. The present meta-analysis inconsistent with the previous meta-analysis suggests that the XRCC3 18067 C>T polymorphism might be implicated in the pathogenesis of cervical and ovarian cancers. |
| Databáze: | OpenAIRE |
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