Characteristics of COPD Smokers and Effectiveness and Safety of Smoking Cessation Medications
| Autor: | Carlos A. Jiménez Ruiz, Marisa Mayayo Ulibarri, Gema Lopez Gonzalez, Angela Ramos Pinedo, Maribel Cristóbal Fernández, Ana Cicero Guerrero |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject Smoking Prevention Comorbidity Nicotine Pulmonary Disease Chronic Obstructive chemistry.chemical_compound Risk Factors Quinoxalines Internal medicine medicine Humans Nicotinic Agonists Sex Distribution Varenicline Aged media_common Bupropion COPD business.industry Smoking Public Health Environmental and Occupational Health Tobacco Use Disorder Benzazepines Middle Aged Abstinence medicine.disease Nicotine replacement therapy Tobacco Use Cessation Devices Obstructive lung disease Causality chemistry Spain Smoking cessation Female Smoking Cessation business medicine.drug |
| Zdroj: | Nicotine & Tobacco Research. 14:1035-1039 |
| ISSN: | 1469-994X 1462-2203 |
| DOI: | 10.1093/ntr/nts001 |
| Popis: | Introduction Smoking is the main cause of chronic obstructive pulmonary disease (COPD), and smoking cessation is the only treatment shown to be effective in arresting the progression of COPD. Different epidemiological and population-based studies have shown smokers with COPD to have specific smoking characteristics that differentiate them from the rest of smokers and which complicate smoking cessation. The main objective of this study is to analyze the effectiveness and safety of drug treatments for smoking cessation in smokers with severe or very severe COPD. Methods Smokers with severe or very severe COPD (Global Initiative for Chronic Obstructive Lung Disease stages III and IV) received treatment for smoking cessation. The treatment program consisted of a combination of behavioral therapy and drug treatment. Patients were followed up at 1, 2, 4, 6, 8, 10, 12, 18, and 24 weeks after the quit date. Results Four hundred seventy-two patients were seen, 65% were male, and their mean age was 58.3 (9.8). They smoked an average of 29.7 (13.4) cigarettes/day, and their mean Fagerstrom test for nicotine dependence score was 7.4 (2.1). Continuous abstinence rate from 9 to 24 weeks (CAR 9-24) was 48.5%. According to type of treatment used, CAR 9-24 for nicotine replacement therapy (NRT), bupropion, and varenicline were 38.2%, 55.6%, and 58.3%, respectively. Varenicline was more effective than nicotine patches: 61% versus 44.1% (odds ratio: 1.98; 95% CI: 1.25-3.12; p = .003). NRT was the treatment producing the fewest adverse effects. The onset of psychiatric symptoms due to medication was rare and evenly distributed across groups. Conclusions This study shows that smokers with severe or very severe COPD are predominantly males with a high degree of physical dependence upon nicotine. CAR 9-24 was 48.5%. Varenicline and bupropion yielded higher abstinence rates than NRT. Varenicline was more effective than nicotine patches: all types of treatments were safe. |
| Databáze: | OpenAIRE |
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