Anti-inflammatory activity of azithromycin as measured by its NF-kappaB, inhibitory activity

Autor:	Kamran Hosseini, Erwin Chun-Chit Si, Paul S. Cheung
Rok vydání:	2010
Předmět:	Hydrocortisone business.industry medicine.drug_class Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal NF-kappa B Pharmacology Azithromycin Orders of magnitude (mass) Anti-inflammatory Dexamethasone Anti-Bacterial Agents Ophthalmology Cell Line Tumor Immunology and Allergy Medicine Potency Humans business IC50 Glucocorticoid medicine.drug
Zdroj:	Ocular immunology and inflammation. 18(1)
ISSN:	1744-5078
Popis:	Growing data suggest that the antibiotic azithromycin mediates anti-inflammatory activity through the inhibition of the transcription factor NF-kappaB. The purpose of this study was to compare azithromycin's anti-inflammatory potency with that of hydrocortisone and dexamethasone as measured in an activated NF-kappaB assay. Dose-response curves and the corresponding inhibitory potencies (IC(50)) of azithromycin, hydrocortisone, and dexamethasone were evaluated in a fluorescence assay using A549 cells. All three compounds inhibited TNFalpha stimulated NF-kappaB activity in a dose-dependent manner. IC(50) values of azithromycin, hydrocortisone and dexamethasone were 56 microM, 2.6 nM, and 0.18 nM, respectively. Hydrocortisone was approximately 4 orders of magnitude more potent than azithromycin, while dexamethasone was approximately 14 times as potent as hydrocortisone. In relative terms the anti-inflammatory potency of azithromycin was about 4 orders of magnitude weaker than that of hydrocortisone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9b08da8c7e4c5ec827e3deefcd9c0b https://pubmed.ncbi.nlm.nih.gov/20128647 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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