The influence of 5-bromodeoxyuridine on DNA repair in Chinese hamster cells exposed to ultraviolet radiation
| Autor: | Jan Cornelis, A. Miller-Faurès, Jean Rommelaere, Maurice Leo Errera |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Time Factors
Cell division DNA Repair DNA repair Chromatography Paper Ultraviolet Rays DNA Single-Stranded Tritium Biochemistry Genetics and Molecular Biology (miscellaneous) Chinese hamster Cell Line chemistry.chemical_compound Cricetinae Centrifugation Density Gradient Animals Ultraviolet radiation 5-Bromodeoxyuridine Genetics biology Dose-Response Relationship Radiation DNA biology.organism_classification Molecular biology Molecular Weight Radiation Effects Dose–response relationship Kinetics chemistry Bromodeoxyuridine Cell culture Spectrophotometry Ultraviolet Cell Division Thymidine |
| Zdroj: | Biochimica et biophysica acta. 340(4) |
| ISSN: | 0006-3002 |
| Popis: | The kinetics and dose dependence were determined both for the repair synthesis and for the induction and repair of single-strand breaks in the 5-bromodeoxyuridine-substituted DNA of ultraviolet-irradiated Chinese hamster cells. A close temporal relationship was observed between repair synthesis and break sealing. The induction of single-strand breaks was linear with dose, whereas a non-linear response was found for repair synthesis. Since almost all breaks were repaired, the calculated number of bases which could be inserted per repaired single-strand break depended on the dose and was close or inferior to a hundred. |
| Databáze: | OpenAIRE |
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