Influence of new deltorphin analogues on reinstatement of cocaine-induced conditioned place preference in rats
| Autor: | Jan Izdebski, Ewa Gibula-Bruzda, Peter W. Schiller, Agnieszka Pachuta, Danuta Kunce, Nga N. Chung, Ewa Witkowska, Jolanta Kotlinska |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Narcotic Antagonists
medicine.medical_treatment Motor Activity Pharmacology Rats Sprague-Dawley chemistry.chemical_compound Cocaine Reward Receptors Opioid delta Conditioning Psychological polycyclic compounds medicine Animals Rats Wistar Maze Learning Receptor Saline business.industry Naltrexone Conditioned place preference Rats Behavior Addictive Sprague dawley Psychiatry and Mental health Infusions Intraventricular Opioid chemistry Deltorphin business Oligopeptides psychological phenomena and processes Behavioral Research medicine.drug |
| Zdroj: | Behavioural Pharmacology. 21:638-648 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/fbp.0b013e32833e7e97 |
| Popis: | The aim of this study was to investigate whether the δ-opioid receptors are involved in the rewarding and reinstatement effect of cocaine in the conditioned place preference (CPP) test. Male Wistar rats were conditioned with cocaine (5 mg/kg) or saline in a biased CPP procedure. The intracerebroventricular (i.c.v.) administration of naltrindole (5 nmol), δ-opioid receptor antagonist but not β-funaltrexamine (5 nmol), or nor-binaltorphimine (10 nmol), μ-opioid and κ-opioid receptor antagonists, respectively reversed the expression of the cocaine CPP. The i.c.v. administration of new analogues of deltorphins with potent agonist activity at δ-opioid receptors, such as cyclo(N, N-carbonyl-D-Orn, Orn)deltorphin (DEL-6) at the dose of 10 and 20 nmol and deltorphin II N-(ureidoethyl)amide (DK-4) at the dose of 10 and 20 nmol reinstated the rewarding effect of cocaine after extinction sessions in the CPP test. Naltrindole (5 nmol, i.c.v.) abolished the reinstated effect of DK-4 (10 nmol). In addition, DEL-6 and DK-4 induce anxiolytic-like effects in the elevated plus-maze test. However, neither peptide given alone either produced a rewarding effect in the CPP test, or influenced the locomotor activity and motor coordination, thus suggesting that these effects of peptides did not influence the results obtained in the reinstatement procedure of CPP. In conclusion, our results show that δ-opioid receptors play a dominant role in cocaine reward and reinstatement of cocaine seeking behavior in the CPP test. |
| Databáze: | OpenAIRE |
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