Induction of Apoptosis by Rewiring the Signal Transduction of Epstein-Barr Virus Oncoprotein LMP1 toward Caspase Activation
| Autor: | George Mosialos, Theodore Tsichritzis, Eudoxia Hatzivassiliou |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Programmed cell death
Immunology Apoptosis Kidney Caspase 8 Microbiology Virus Cell Line Viral Matrix Proteins Virology otorhinolaryngologic diseases Humans Caspase Viral matrix protein biology Virus-Cell Interactions Cell biology stomatognathic diseases Cell culture Caspases Insect Science biology.protein Signal transduction Signal Transduction |
| Zdroj: | Journal of Virology. 79:5215-5219 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The Epstein-Barr virus latent membrane protein 1 (LMP1) is an oncoprotein which mimics activated tumor necrosis factor receptor family members. Here we demonstrate the principle that an inducible association of the LMP1 cytoplasmic carboxyl terminus with caspase-8 by a heterodimerizing agent causes apoptosis. This process depends on the catalytic activity of caspase-8 and the ability of LMP1 to oligomerize constitutively at the plasma membrane. Our data indicate that chemical inducers of the association of the LMP1 carboxyl terminus with caspase-8 can kill LMP1-expressing cells selectively. Such compounds could be used as chemotherapeutic agents for LMP1-associated malignancies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|