Factors influencing the internalization of Staphylococcus aureus and impacts on the course of infections in humans
| Autor: | M C Hudson, E H Alexander |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Staphylococcus aureus
media_common.quotation_subject General Medicine Staphylococcal Infections Biology Endocytosis Staphylococcal infections medicine.disease Microfilament medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Mice Eukaryotic Cells Extracellular medicine Animals Humans Internalization Pathogen Intracellular Biotechnology media_common |
| Zdroj: | Applied Microbiology and Biotechnology. 56:361-366 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/s002530100703 |
| Popis: | Staphylococcus aureus is the primary etiological agent of several human diseases. S. aureus has classically been considered an extracellular pathogen; however, recent evidence indicates that S. aureus invades and persists in non-professional phagocytes. Experiments demonstrate that actin microfilaments, microtubules, receptor-mediated endocytosis, and protein tyrosine kinases play important roles in the uptake of S. aureus. Fibronectin-binding proteins and beta-integrins are implicated as critical cell surface molecules associated with internalization of S. aureus by non-phagocytic cells. Following invasion of eukaryotic cells, S. aureus induces the release of cytokines that have the potential to exacerbate disease and induce apoptosis. Finally, S. aureus has the ability to persist inside host cells as small colony variants, a phenotype associated with persistent and recurrent infections. |
| Databáze: | OpenAIRE |
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