Hypersensitivity pneumonitis: Clinical manifestations – Prospective data from the interstitial lung disease-India registry
Autor: | Subodh K Katiyar, Sudhakar Pipavath, Sudhir Chaudhari, Jitesh Ahuja, Mangal Dk, Deepak Talwar, Parvaiz A Koul, Bharat Bhushan Sharma, Nishtha Singh, Ravindran Chetambath, Surya Kant, Raja Dhar, Jyotsana M. Joshi, H. J. Gayathri Devi, Sandeep Katiyar, Sheetu Singh, Virendra Singh, Ganesh Raghu, Khushboo Pilania, Rajesh Swarnakar, Lawrence A. Ho, Arpita Jindal, Bridget F. Collins, Jai Kumar Samaria, Nirmal Kumar Jain, Parthasarthi Bhattacharya, Tejraj Singh, Aloke Gopal Ghoshal |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Pulmonary and Respiratory Medicine
lcsh:RC705-779 medicine.medical_specialty business.industry Environmental exposures Interstitial lung disease Prospective data Extrinsic Allergic Alveolitis Context (language use) extrinsic allergic alveolitis Odds ratio lcsh:Diseases of the respiratory system medicine.disease Confidence interval 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine medicine Original Article 030212 general & internal medicine Medical diagnosis business hypersensitivity pneumonitis Hypersensitivity pneumonitis |
Zdroj: | Lung India : Official Organ of Indian Chest Society Lung India, Vol 36, Iss 6, Pp 476-482 (2019) |
ISSN: | 0974-598X 0970-2113 |
Popis: | Context: Multiple environmental factors are associated with development of hypersensitivity pneumonitis (HP), and diagnostic algorithms for the diagnosis of HP have been proposed in recent perspectives. Aims: We analyzed the data of patients with HP from interstitial lung disease (ILD)-India registry. The analysis was performed to (1) find the prevalence of HP, (2) reclassify HP as per a recently proposed classification criterion to assess the level of diagnostic certainty, and (3) identify the causative agents for HP. Setting and Designs: This was a prospective multicenter study of consecutive, consenting adult patients with new-onset ILD from 27 centers across India (March 2012–April 2015). Materials and Methods: The diagnoses were based on prespecified working clinical criteria and multidisciplinary discussions. To assess strength of diagnosis based on available clinical information, patients with HP were subclassified into definite HP, HP with high level of confidence, and HP with low level of confidence using a recent classification scheme. Results: Five hundred and thirteen of 1084 patients with new-onset ILD were clinically diagnosed with HP and subclassified as HP with high level of confidence (380, 74.1%), HP with low level of confidence (106, 20.7%), and definite HP (27, 5.3%). Exposures among patients with HP were birds (odds ratios [OR]: 3.52, P < 0.001), air-conditioners (OR: 2.23, P < 0.001), molds (OR: 1.79, P < 0.001), rural residence (OR: 1.64, P < 0.05), and air-coolers (OR: 1.45, P < 0.05). Conclusions: About 47.3% of patients with new-onset ILD in India were diagnosed with HP, the majority of whom were diagnosed as HP with a high level of confidence. The most common exposures were birds, cooling devices, and visible molds. |
Databáze: | OpenAIRE |
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