Image guided radiation therapy may result in improved local control in locally advanced lung cancer patients
| Autor: | Scott Isom, W.T. Kearns, William J. Petty, J.M. Kilburn, William H. Hinson, John T. Lucas, D.N. Ayala-Peacock, William Blackstock, James J. Urbanic, Antonius A. Miller, Michael T. Munley, Michael H. Soike |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Lung Neoplasms medicine.medical_treatment Article Disease-Free Survival 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences 0302 clinical medicine Clinical Research 80 and over medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Cancer Aged Retrospective Studies Image-guided radiation therapy Aged 80 and over Univariate analysis Radiotherapy medicine.diagnostic_test business.industry Hazard ratio Evaluation of treatments and therapeutic interventions Retrospective cohort study Middle Aged medicine.disease Radiation therapy Treatment Outcome Image-Guided Oncology Positron emission tomography 6.1 Pharmaceuticals 030220 oncology & carcinogenesis Cohort Biomedical Imaging Female Nuclear medicine business Radiotherapy Image-Guided |
| Zdroj: | Practical radiation oncology, vol 6, iss 3 |
| ISSN: | 1879-8500 |
| DOI: | 10.1016/j.prro.2015.10.004 |
| Popis: | Purpose Image guided radiation therapy (IGRT) is designed to ensure accurate and precise targeting, but whether improved clinical outcomes result is unknown. Methods and materials A retrospective comparison of locally advanced lung cancer patients treated with and without IGRT from 2001 to 2012 was conducted. Median local failure-free survival (LFFS), regional, locoregional failure-free survival (LRFFS), distant failure-free survival, progression-free survival, and overall survival (OS) were estimated. Univariate and multivariate models assessed the association between patient- and treatment-related covariates and local failure. Results A total of 169 patients were treated with definitive radiation therapy and concurrent chemotherapy with a median follow-up of 48 months in the IGRT cohort and 96 months in the non-IGRT cohort. IGRT was used in 36% (62 patients) of patients. OS was similar between cohorts (2-year OS, 47% vs 49%, P = .63). The IGRT cohort had improved 2-year LFFS (80% vs 64%, P = .013) and LRFFS (75% and 62%, P = .04). Univariate analysis revealed IGRT and treatment year improved LFFS, whereas group stage, dose, and positron emission tomography/computed tomography planning had no impact. IGRT remained significant in the multivariate model with an adjusted hazard ratio of 0.40 ( P = .01). Distant failure-free survival (58% vs 59%, P = .67) did not differ significantly. Conclusion IGRT with daily cone beam computed tomography confers an improvement in the therapeutic ratio relative to patients treated without this technology. |
| Databáze: | OpenAIRE |
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