Michael-type reaction of ethyl bromodifluoroacetate with alpha,beta- unsaturated carbonyl compounds in the presence of copper powder

Autor:	Kazuyuki Sato, Kei Tamoto, Akira Ando, Misato Tamura, Masaaki Omote, Itsumaro Kumadaki
Rok vydání:	2000
Předmět:	Fluoroacetates chemistry.chemical_element General Chemistry General Medicine Acceptor Copper Medicinal chemistry chemistry.chemical_compound chemistry Group (periodic table) Drug Discovery Phenyl group Organic chemistry
Zdroj:	Chemicalpharmaceutical bulletin. 48(7)
ISSN:	0009-2363
Popis:	We have reported that the reaction of ethyl bromodifluoroacetate (1) with alkenyl iodides in the presence of copper powder gives ethyl alkenyldifluoroacetates. As an extension of this reaction, reaction of 1 with Michael acceptors in the presence of copper powder was examined and found to give 1,4-addition products selectively, unless the acceptor has a group stabilizing a radical intermediate, such as a phenyl group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f92633b7e31624b15f3a5f5b6513237 https://pubmed.ncbi.nlm.nih.gov/10923834 Zobrazit plný text záznamu