Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia
| Autor: | Kiattawee Choowongkomon, Khuanjarat Choengpanya, Supaphorn Seetaha, Lueacha Tabtimmai, Siriluk Ratanabunyong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Anti hiv 1 Mushrooms QH301-705.5 Human immunodeficiency virus (HIV) Biology medicine.disease_cause 01 natural sciences 03 medical and health sciences Ethanol extracts Acquired immunodeficiency syndrome (AIDS) Ic50 values medicine Hiv treatment Biology (General) chemistry.chemical_classification Traditional medicine medicine.disease Reverse transcriptase 030104 developmental biology Enzyme chemistry Original Article HIV-1 reverse transcriptase Crude extracts Anti-HIV-1 agents General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 5, Pp 2807-2815 (2021) Saudi Journal of Biological Sciences |
| Popis: | Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), which is a serious health threat worldwide. One of its core enzymes, reverse transcriptase (RT), is a target for HIV inhibition. A number of bioactive compounds have been successfully used for HIV treatment. However, HIV rapidly mutates, and long-term treatment can cause drug-resistant strains. Therefore, new inhibitors are required to overcome this problem. In this study, the aqueous, ethanolic and hexane crude extracts of 19 edible and medicinal mushrooms, which are widely grown and available commercially in Thailand, were screened against HIV-1 RT. The results showed that the water extracts of A. blazei and I. obliquus, the ethanol extracts of I. obliquus and P. igniarius and the hexane extract of I. obliquus exhibited strong anti-HIV-1 RT activity with IC50 values of 1.92 ± 0.15, 4.39 ± 0.79, 6.17 ± 0.76 and 7.75 ± 246 µg/ml, respectively. These mushrooms have the potential for HIV treatment, and further study on identification of the bioactive compounds against HIV-1 RT should be performed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|