Cohort profile:Bandim Health Project's (BHP) rural Health and Demographic Surveillance System (HDSS) - A nationally representative HDSS in Guinea-Bissau
| Autor: | Manuel Fernandes, Christine Stabell Benn, Ane Bærent Fisker, Peter Aaby, Sanne Marie Thysen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Rural Population Tuberculosis Maternal-Child Health Services Epidemiology 030231 tropical medicine Psychological intervention Rural Health Measles 03 medical and health sciences 0302 clinical medicine Pregnancy Environmental health Humans Medicine Guinea-Bissau Public Health Surveillance 030212 general & internal medicine health and demographic surveillance system Cohort Profile business.industry maternal mortality Rural health Vaccination Child Health General Medicine medicine.disease Quality Improvement Child mortality non-specific (heterologous) effects of vaccines Child Preschool Cohort Women's Health Female business Demographic surveillance system community child health |
| Zdroj: | Thysen, S M, Fernandes, M, Benn, C S, Aaby, P & Fisker, A B 2019, ' Cohort profile : Bandim Health Project's (BHP) rural Health and Demographic Surveillance System (HDSS)-A nationally representative HDSS in Guinea-Bissau ', BMJ Open, vol. 9, no. 6, e028775 . https://doi.org/10.1136/bmjopen-2018-028775 BMJ Open BMJ Open, Vol 9, Iss 6 (2019) |
| DOI: | 10.1136/bmjopen-2018-028775 |
| Popis: | PurposeBandim Health Project (BHP) monitors health and survival of women and children in a nationally representative rural Health and Demographic Surveillance System (HDSS) in Guinea-Bissau. The HDSS was set up in 1989–1990 to collect data on health interventions and child mortality.ParticipantsThe HDSS covers 182 randomly selected clusters across the whole country. The cohort is open, and women and children enter the cohort, when they move into the selected clusters, and leave the cohort, when they move out or die, or when children reach 5 years of age. Data are collected through biannual or more frequent household visits. At all village visits, information on pregnancies, vital status, vaccination status, arm circumference, use of bed nets and other basic information is collected for women and children. Today, more than 25 000 women and 23 000 children below the age of 5 years are under surveillance.Findings to dateResearch from the BHP has given rise to the hypothesis that vaccines, in addition to their targeted effects, have important non-specific effects altering the susceptibility to other infections. Initially, it was observed that mortality among children vaccinated with the live BCG or measles vaccines was much lower than the mortality among unvaccinated children, a difference, which could not be explained by prevention of tuberculosis and measles infections. In contrast, mortality tended to be higher for children who had received the non-live Diphtheria-Tetanus-Pertussis vaccine compared with children who had not received this vaccine. Since the effect differed for the different vaccines, no bias explained the contrasting findings.Future plansNew health interventions are introduced with little assessment of real-life effects. Through the HDSS, we can describe both the implementation of interventions (eg, the vaccination programme) and their effects. Furthermore, the intensive follow-up allows the implementation of randomised trials testing potential better vaccination programmes. |
| Databáze: | OpenAIRE |
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