Involvement of the endocannabinoid system in reward processing in the human brain

Autor: Joop M. A. van Gerven, René S. Kahn, Matthijs G. Bossong, J. Martijn Jansma, Lineke Zuurman, Nick F. Ramsey, Gerry Jager, Hendrika H. van Hell, Annelies Brouwer
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
cannabinoid cb1 receptors
delta-9-tetrahydrocannabinol
clinical-research
0302 clinical medicine
Healthy volunteers
Delta-9-tetrahydrocannabinol
Dronabinol
Sensory Science and Eating Behaviour
Original Investigation
media_common
Feedback
Physiological
Cross-Over Studies
fMRI
Brain
Human brain
Magnetic Resonance Imaging
Endocannabinoid system
Anticipation
medicine.anatomical_structure
Psychology
psychological phenomena and processes
Cognitive psychology
Adult
Adolescent
media_common.quotation_subject
neural-basis
Addiction
Reward processing
acute oral delta(9)-tetrahydrocannabinol
Young Adult
03 medical and health sciences
human striatum
Reward
Cannabinoid Receptor Modulators
mental disorders
Reaction Time
medicine
Humans
VLAG
Pharmacology
healthy-volunteers
thc
decision-making
Anticipation
Psychological
030227 psychiatry
Sensoriek en eetgedrag
Monetary reward
Curiosity
dopamine release
Neuroscience
030217 neurology & neurosurgery
Endocannabinoids
Zdroj: Psychopharmacology, 219(4), 981-990
Psychopharmacology 219 (2012) 4
Psychopharmacology
ISSN: 0033-3158
DOI: 10.1007/s00213-011-2428-8
Popis: Rationale Disturbed reward processing in humans has been associated with a number of disorders, such as depression, addiction, and attention-deficit hyperactivity disorder. The endocannabinoid (eCB) system has been implicated in reward processing in animals, but in humans, the relation between eCB functioning and reward is less clear. Objectives The current study uses functional magnetic resonance imaging (fMRI) to investigate the role of the eCB system in reward processing in humans by examining the effect of the eCB agonist Δ9-tetrahydrocannabinol (THC) on reward-related brain activity. Methods Eleven healthy males participated in a randomized placebo-controlled pharmacological fMRI study with administration of THC to challenge the eCB system. We compared anticipatory and feedback-related brain activity after placebo and THC, using a monetary incentive delay task. In this task, subjects are notified before each trial whether a correct response is rewarded (“reward trial”) or not (“neutral trial”). Results Subjects showed faster reaction times during reward trials compared to neutral trials, and this effect was not altered by THC. THC induced a widespread attenuation of the brain response to feedback in reward trials but not in neutral trials. Anticipatory brain activity was not affected. Conclusions These results suggest a role for the eCB system in the appreciation of rewards. The involvement of the eCB system in feedback processing may be relevant for disorders in which appreciation of natural rewards may be affected such as addiction. Electronic supplementary material The online version of this article (doi:10.1007/s00213-011-2428-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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