Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)
Autor: | Jordi Salas-Salvadó, Juan J. Moreno, Miguel Ángel Martínez-González, Ramon Estruch, Anna Tresserra-Rimbau, Xavier Pi-Sunyer, Rosa M. Lamuela-Raventós, Xiaohui Guo, María P. Portillo, Montserrat Fitó, Alexander Medina-Remón, Dolores Corella |
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Přispěvatelé: | Universitat de Barcelona, Alimentació, Nutrició, Creixement i Salut Mental, Bioquímica i Biotecnologia, Universitat Rovira i Virgili |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male obesity Cross-sectional study Urine Overweight Body Mass Index Surveys and Questionnaires Prevalence Ciències de la salut Waist-to-height ratio Nutrition and Dietetics Confounding Middle Aged Ciencias de la salud urine Polifenols Obesitat Female medicine.symptom Waist Circumference PREDIMED medicine.medical_specialty Waist Article 03 medical and health sciences Internal medicine medicine Humans overweight Obesity Aged 030109 nutrition & dietetics Waist-Height Ratio business.industry Body Weight Health sciences Polyphenols NUTRICIÓ polyphenol DIETOTERÀPIA 2072-6643 medicine.disease Surgery Cross-Sectional Studies Nutrition Assessment business Body mass index Biomarkers Food Science Follow-Up Studies |
Zdroj: | Nutrients Recercat. Dipósit de la Recerca de Catalunya instname Nutrients; Volume 9; Issue 5; Pages: 452 Dipòsit Digital de la UB Universidad de Barcelona |
ISSN: | 2072-6643 |
DOI: | 10.3390/nu9050452 |
Popis: | Overweight and obesity have been steadily increasing in recent years and currently represent a serious threat to public health. Few human studies have investigated the relationship between polyphenol intake and body weight. Our aim was to assess the relationship between urinary polyphenol levels and body weight. A cross-sectional study was performed with 573 participants from the PREDIMED (Prevención con Dieta Mediterránea) trial (ISRCTN35739639). Total polyphenol levels were measured by a reliable biomarker, total urinary polyphenol excretion (TPE), determined by the Folin-Ciocalteu method in urine samples. Participants were categorized into five groups according to their TPE at the fifth year. Multiple linear regression models were used to assess the relationships between TPE and obesity parameters; body weight (BW), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). After a five years follow up, significant inverse correlations were observed between TPE at the 5th year and BW (β = -1.004; 95% CI: -1.634 to -0.375, p = 0.002), BMI (β = -0.320; 95% CI: -0.541 to -0.098, p = 0.005), WC (β = -0.742; 95% CI: -1.326 to -0.158, p = 0.013), and WHtR (β = -0.408; 95% CI: -0.788 to -0.028, p = 0.036) after adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute to reducing body weight in elderly people at high cardiovascular risk. We thank all the participants of the PREDIMED study. This work was supported in part by CICYT (AGL2016-79113-R), the Instituto de Salud Carlos III, ISCIII (CIBEROBN) from the Spanish Ministry of Economy and Competivity (MEC), and Generalitat de Catalunya (GC) 2014 SGR 773. X.G. received support from China Scholarship Council (CSC). Alexander Medina-Remón thanks the ‘Juan de la Cierva’ postdoctoral program (JCI-2012-13463) from MEC. |
Databáze: | OpenAIRE |
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