Ricin B-chain promotes the internalisation of liposomal contents into rat hepatoma cells
| Autor: | Martin H. Friede, Claus von Holt |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Protein Conformation
Biophysics Ricin Biochemistry chemistry.chemical_compound Membrane Lipids Liver Neoplasms Experimental Tumor Cells Cultured Animals Deoxyribonuclease I Binding site Cytotoxicity chemistry.chemical_classification Liposome biology Cell Membrane Lectin Cell Biology Transfection Rats carbohydrates (lipids) Methotrexate chemistry Liposomes biology.protein Microscopy Electron Scanning Glycoprotein Intracellular |
| Zdroj: | Biochimica et biophysica acta. 1069(2) |
| ISSN: | 0006-3002 |
| Popis: | Ricin B-chain covalently attached to liposomes has been shown to promote the binding of the liposomes to rat hepatoma cells through its galactosyl binding site. Internalisation of the bound liposomes is demonstrated by the cytoxicity of methotrexate-containing liposomes, the transfection of cells with targeted liposomes containing pSV2-neo DNA and the intracellular activity of an enzyme encapsulated in liposomes targeted with the ricin B-chain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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